Updated Jun. 26, 2023
Mayu Shono, PhD student, Akihisa Shioi, Professor at the Faculty of Science and Engineering, and their colleagues devise a new method for producing cell-sized microgel structures using water/water phase separation.
Real-world models that mimic living cells can be invaluable in studying their complex structure and assembly. Microdroplets that entrap biological materials are a prototype of these models, which can be generated using synthetic processes but are expensive, time-consuming, and experimentally demanding. Shioi and his team have now used water/water phase separation to produce uniform gelatin-based cell mimetics called “microgels”, which can contribute towards the smart manufacturing of food, cosmetics, and medicines.
https://doi.org/10.1002/smll.202302193
For more details, please see the website of Organization for Research Initiatives and Development, Doshisha University.
Research News:Smart yet Simple – Creating Uniform DNA-encapsulating Microgels that Mimic a Living Cell
This achievement has also been featured in the “EurekAlert!.”
NEWS RELEASE 23-JUN-2023, Smart yet simple – creating uniform DNA-encapsulating microgels that mimic a living cell
Real-world models that mimic living cells can be invaluable in studying their complex structure and assembly. Microdroplets that entrap biological materials are a prototype of these models, which can be generated using synthetic processes but are expensive, time-consuming, and experimentally demanding. Shioi and his team have now used water/water phase separation to produce uniform gelatin-based cell mimetics called “microgels”, which can contribute towards the smart manufacturing of food, cosmetics, and medicines.
Reference
Shono, M., Honda, G., Yanagisawa, M., Yoshikawa, K. and Shioi, A. (2023), Spontaneous Formation of Uniform Cell-Sized Microgels through Water/Water Phase Separation. Small 2302193.https://doi.org/10.1002/smll.202302193
For more details, please see the website of Organization for Research Initiatives and Development, Doshisha University.
Research News:Smart yet Simple – Creating Uniform DNA-encapsulating Microgels that Mimic a Living Cell
This achievement has also been featured in the “EurekAlert!.”
NEWS RELEASE 23-JUN-2023, Smart yet simple – creating uniform DNA-encapsulating microgels that mimic a living cell
By adapting aqueous polymer solution containing DNA, droplets entrapping DNA are generated in a self-organized manner through micro phase-separation, and these droplets are transformed into gel state by decreasing the temperature. The microgels are easily extruded into bulk water, maintaining their size.
Image Credit: Akihisa Shioi from Doshisha University
Image Source Link: https://onlinelibrary.wiley.com/cms/asset/f9e61815-bbf5-4c11-a509-e0ee212d68c8/smll202302193-gra-0001-m.jpg
License type: CC BY-NC 4.0
Mayu Shono, PhD student, Akihisa Shioi, Professor at the Faculty of Science and Engineering, and their colleagues devise a new method for producing cell-sized microgel structures using water/water phase separation.
Real-world models that mimic living cells can be invaluable in studying their complex structure and assembly. Microdroplets that entrap biological materials are a prototype of these models, which can be generated using synthetic processes but are expensive, time-consuming, and experimentally demanding. Shioi and his team have now used water/water phase separation to produce uniform gelatin-based cell mimetics called “microgels”, which can contribute towards the smart manufacturing of food, cosmetics, and medicines.
https://doi.org/10.1002/smll.202302193
For more details, please see the website of Organization for Research Initiatives and Development, Doshisha University.
Research News:Smart yet Simple – Creating Uniform DNA-encapsulating Microgels that Mimic a Living Cell
This achievement has also been featured in the “EurekAlert!.”
NEWS RELEASE 23-JUN-2023, Smart yet simple – creating uniform DNA-encapsulating microgels that mimic a living cell
Real-world models that mimic living cells can be invaluable in studying their complex structure and assembly. Microdroplets that entrap biological materials are a prototype of these models, which can be generated using synthetic processes but are expensive, time-consuming, and experimentally demanding. Shioi and his team have now used water/water phase separation to produce uniform gelatin-based cell mimetics called “microgels”, which can contribute towards the smart manufacturing of food, cosmetics, and medicines.
Reference
Shono, M., Honda, G., Yanagisawa, M., Yoshikawa, K. and Shioi, A. (2023), Spontaneous Formation of Uniform Cell-Sized Microgels through Water/Water Phase Separation. Small 2302193.https://doi.org/10.1002/smll.202302193
For more details, please see the website of Organization for Research Initiatives and Development, Doshisha University.
Research News:Smart yet Simple – Creating Uniform DNA-encapsulating Microgels that Mimic a Living Cell
This achievement has also been featured in the “EurekAlert!.”
NEWS RELEASE 23-JUN-2023, Smart yet simple – creating uniform DNA-encapsulating microgels that mimic a living cell