Spotlights

Molecular desorption from a microbubble under ultrasound irradiation.
The amount of molecular desorption can be estimated quantitatively by the proposed method.

A research team headed by Professor Daisuke Koyama and graduate student Ms. Reina Kobayashi, from the Faculty of Science and Engineering, reported, “novel measurement technique can help develop targeted therapeutic strategies that use microbubbles and ultrasound to deliver drugs to specific locations.”
Vascular drug therapies often lead to undesirable side effects on healthy tissues. Addressing this issue requires targeted drug delivery systems. They have recently developed an innovative approach for measuring the amount of molecules desorbed from the surface of individual microbubbles when irradiated with ultrasound. Using this technique, they analyzed the desorption process in detail, revealing insights that could enable the design of next-generation drug delivery systems based on drug-loaded microbubbles and ultrasound.

Reference
I Kobayashi R., Narita J., Nakaoka N., Krafft M.P., Koyama D. Quantitative estimation of phospholipid molecules desorbed from a microbubble surface under ultrasound irradiation (2023) Scientific Reports, 13 (1), art. no. 13693.
DOI: 10.1038/s41598-023-40823-0

For more details, please see the website of Organization for Research Initiatives and Development, Doshisha University.
Research News: Unveiling the Science of Ultrasound-Driven Microbubble Desorption

This achievement has also been featured in the “EurekAlert!.”
NEWS RELEASE 21-SEP-2023 Unveiling the Science of Ultrasound-Driven Microbubble Desorption


Image Credit:Daisuke Koyama and Reina Kobayashi
License type: Original content