Doshisha University
  • Home
  • Contact
  • Access & Campus Map
Spotlight
  1. Home
  2.  > Spotlights AY2017
  3.  > Research Results of Associate Professor Kitagishi’s Group (Faculty of Science and Engineering) Published in Journal of the American Chemical Society

Research Results of Associate Professor Kitagishi’s Group (Faculty of Science and Engineering) Published in Journal of the American Chemical Society

Related Categories  : Research & Partnerships
Updated Apr. 24, 2017
The achievement of the research group led by Associate Professor Hiroaki Kitagishi, et al. of the Faculty of Science and Engineering has been published in the Journal of the American Chemical Society.

Known as a poisonous gas, Carbon monoxide (CO) is generated in minute amounts in the bodies of living organisms and possesses various physiological functions. The research group of Associate Professor Kitagishi, et al. developed a new technology to selectively capture CO in the living bodies using an independently developed chemical compound called hemoCD. This technique enables the easy measurement of endogenously produced CO in tissues and cells without the need of a special device. It can also easily detect what kinds of physiological functions CO has in cells by introducing hemoCD into cells.
Carbon monoxide is an endogenously produced gas as important as nitric monoxide for which the Nobel Prize in Physiology or Medicine was awarded in 1998, and the full elucidation of its physiological functions is expected.

This research project was carried out with the support of the MEXT-supported Program for the Strategic Research Foundation at Private Universities, ‘Formation of a development base of molecular chemistry technologies for freely manipulating cells’ (2015-2019, representative: Professor Masahito Kodera).

Journal carrying the article:
‘Journal of the American Chemical Society’ (DOI: 10.1021/jacs.7b02229)

Title of Article:
‘Detection and Removal of Endogenous Carbon Monoxide by Selective and Cell-permeable Hemoprotein Model Complexes’

Authors:
Saika Minegishi (Second year, Doctoral Program in Applied Chemistry, Graduate School of Science and Engineering)
Aki Yumura (Master’s Program in Applied Chemistry, Graduate School of Science and Engineering, completed in 2014)
Hirotsuna Miyoshi (Master’s Program in Applied Chemistry, Graduate School of Science and Engineering, completed in 2016)
Shigeru Negi (Doshisha Women’s College of Liberal Arts)
Shigeru Taketani (Kansai Medical University)
Roberto Motterlini (Inserm U955, France)
Roberta Foresti (Inserm U955, France)
Koji Kano (Professor Emeritus of Doshisha University)
Hiroaki Kitagishi (Associate Professor, Faculty of Science and Engineering)