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[Research News] A Novel Heme-Model Compound that Treats Lethal Gas Poisoning

Dec.11,2024 Update

20240327ResearchNews Structures of met-hemoCD-P and met-hemoCD-I
These compounds can act as powerful antidotes to treat carbon monoxide, hydrogen cyanide, and hydrogen sulfide poisoning without any risk of side effects.※
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Professor Hiroaki Kitagishi, Department of Molecular Chemistry and Biochemistry, and his colleagues have developed a synthetic, nontoxic antidote to treat hydrogen sulfide poisoning safely.

Hydrogen sulfide binds strongly to heme-containing enzymes in the cell and blocks the process of respiration, causing rapid death at higher concentrations. Now, Kitagishi and his team have developed an artificial heme-model compound that has a high affinity for hydrogen sulfide and binds to it much faster than human met-hemoglobin. This compound, met-hemoCD-I, successfully treated hydrogen sulfide-induced toxicity in mice, indicating its potential as an antidote.

Reference
Atsuki Nakagami, Qiyue Mao, Masaki Horitani, Masahito Kodera & Hiroaki Kitagishi. Detoxification of hydrogen sulfide by synthetic heme model compounds. (2024) Scientific Reports.
https://doi.org/10.1038/s41598-024-80511-1

For more details, please see the website of Organization for Research Initiatives and Development, Doshisha University.
A Novel Heme-Model Compound that Treats Lethal Gas Poisoning

This achievement has also been featured in the “EurekAlert!.”NEWS RELEASE 11-DEC-2024, 
[Research News] A Novel Heme-Model Compound that Treats Lethal Gas Poisoning


Credit: The authors
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