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[Research News] Advancing Tissue Engineering with Shape Memory Hydrogels

Mar.15,2024 Update

DOSIU_38_Press_Release_Image.jpg (87810) Developing hydrogel scaffolds with tunable elastic modulus for tissue engineering
Researchers have developed a hydrogel composed of poly(N-acryloylglycinamide) (PNAGAm) grafted with arginine (R)–glycine (G)–aspartic acid (D)–serine (S) peptide whose elastic modulus can be changed by simply compressing it to different thicknesses.

A research team led by Assistant Professor Shin-nosuke Nishimura and Professor Tomoyuki Koga at the Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, demonstrate a hydrogel system possessing the ability to remember its shape, offering a unique platform for controlling cell adhesion behavior.

Artificial scaffolds play an important role in tissue healing and growth. The properties of a scaffold, especially its elasticity, impact cell growth. However, adjusting the elasticity without altering composition and other properties has been challenging. Now, researchers at Doshisha University have successfully created a hydrogel with a tunable elastic modulus with the same composition. This breakthrough allows, for the first time, the control of cell adhesion on a hydrogel by adjusting the elastic modulus. Artificial scaffolds play an important role in tissue healing and growth. The properties of a scaffold, especially its elasticity, impact cell growth. However, adjusting the elasticity without altering composition and other properties has been challenging. Now, Nishimura and his colleagues have successfully created a hydrogel with a tunable elastic modulus with the same composition. This breakthrough allows, for the first time, the control of cell adhesion on a hydrogel by adjusting the elastic modulus.

Reference
Nishimura S.-N., Yoshida T., Higashi N., Koga T. Regulation of Cell Adhesion on Physically Crosslinked Hydrogels Composed of Amino Acid-Based Polymers by Changing Elastic Modulus Using Shape Fix/Memory Properties (2024) Advanced Materials Technologies
DOI:10.1002/admt.202301598

For more details, please see the website of Organization for Research Initiatives and Development, Doshisha University.
Research News: Advancing Tissue Engineering with Shape Memory Hydrogels

This achievement has also been featured in the “EurekAlert!”.
NEWS RELEASE 13-MAR-2024 Advancing Tissue Engineering with Shape Memory Hydrogels

Image Credit: Umargani Jamal Mohamed from Openverse




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