Spotlight

  1. Home
  2. Spotlights AY2022
  3. [Research News] Newly Identified Compound Binds to Shiga Toxin to Reduce its Toxicity

[Research News] Newly Identified Compound Binds to Shiga Toxin to Reduce its Toxicity

Related Categories
Updated Aug. 5, 2022
NISHIKAWA Kiyotaka, Professor at the Faculty of Biomedical Sciences; WATANABE-TAKAHASHI Miho, Assistant Professor at the Faculty of Biomedical Sciences; and the colleagues have discovered a compound that binds to and selectively inhibits a lethal subtype of the “Shiga toxin”, a deadly toxin which causes bloody diarrhea and severe abdominal cramps in humans.

Reference
Miho Watanabe-Takahashi, Miki Senda, Ryunosuke Yoshino, Masahiro Hibino, Shinichiro Hama, Tohru Terada, Kentaro Shimizu, Toshiya Senda, and- Kiyotaka Nishikawa. A unique peptide-based pharmacophore identifies an inhibitory compound against the A-subunit of Shiga toxin. Sci Rep 12, 11443 (2022).
https://doi.org/10.1038/s41598-022-15316-1

For more details, please see the link below.
Research News: Newly Identified Compound Binds to Shiga Toxin to Reduce its Toxicity (Website of Doshisha University Organization for Research Initiatives and Development)

This achievement has also been featured in the “EurekAlert!”.
Newly identified compound binds to Shiga toxin to reduce its toxicity (EurekAlert!)
Structural view of binding between the Stx2a A-subunit and compound #6

Structural view of binding between the Stx2a A-subunit and compound #6
Credit: Prof. Kiyotaka Nishikawa from Doshisha University, Japan

NISHIKAWA Kiyotaka, Professor at the Faculty of Biomedical Sciences; WATANABE-TAKAHASHI Miho, Assistant Professor at the Faculty of Biomedical Sciences; and the colleagues have discovered a compound that binds to and selectively inhibits a lethal subtype of the “Shiga toxin”, a deadly toxin which causes bloody diarrhea and severe abdominal cramps in humans.

Reference
Miho Watanabe-Takahashi, Miki Senda, Ryunosuke Yoshino, Masahiro Hibino, Shinichiro Hama, Tohru Terada, Kentaro Shimizu, Toshiya Senda, and- Kiyotaka Nishikawa. A unique peptide-based pharmacophore identifies an inhibitory compound against the A-subunit of Shiga toxin. Sci Rep 12, 11443 (2022).
https://doi.org/10.1038/s41598-022-15316-1

For more details, please see the link below.
Research News: Newly Identified Compound Binds to Shiga Toxin to Reduce its Toxicity (Website of Doshisha University Organization for Research Initiatives and Development)

This achievement has also been featured in the “EurekAlert!”.
Newly identified compound binds to Shiga toxin to reduce its toxicity (EurekAlert!)
Contact
Department of Research Planning
Telephone : +81-774-65-8256
Fax : +81-774-65-7757
E-mail:ji-knkak@mail.doshisha.ac.jp
Contact Us