Updated Feb. 1, 2023
The study, led by Associate Professor Yuki Hashimotodani and included contributions from graduate student Himawari Hirai and Professor Takeshi Sakaba from the Graduate School of Brain Science, explores the synaptic plasticity in the links between specific regions of the hypothalamus and the hippocampus. Neuronal synapses often undergo lasting changes in their strength through neural activity, known as “synaptic plasticity.” They show that glutamate-mediated synapses from the hypothalamic supramammillary nucleus to the granule cells in the dentate gyrus undergo associative long-term potentiation. These findings can enable a more comprehensive understanding of learning and memory.
https://doi.org/10.1016/j.celrep.2022.111871.
For more details, please see the website of Organization for Research Initiatives and Development, Doshisha University.
Research News: Understanding Long-term Changes in the Synapses Between the Hypothalamus and Hippocampus
This achievement has also been featured in the “EurekAlert!.”
NEWS RELEASE 30-JAN-2023, Understanding long-term changes in the synapses between the hypothalamus and hippocampus
Reference
Himawari Hirai, Takeshi Sakaba, Yuki Hashimotodani, Subcortical glutamatergic inputs exhibit a Hebbian form of long-term potentiation in the dentate gyrus, Cell Reports, Volume 41, Issue 13, 2022, 111871, ISSN 2211-1247,https://doi.org/10.1016/j.celrep.2022.111871.
For more details, please see the website of Organization for Research Initiatives and Development, Doshisha University.
Research News: Understanding Long-term Changes in the Synapses Between the Hypothalamus and Hippocampus
This achievement has also been featured in the “EurekAlert!.”
NEWS RELEASE 30-JAN-2023, Understanding long-term changes in the synapses between the hypothalamus and hippocampus
Understanding learning and memory in some of the synapses between the hypothalamus and the hippocampus.
Image credit: Yuki Hashimotodani from Doshisha University, Japan
The study, led by Associate Professor Yuki Hashimotodani and included contributions from graduate student Himawari Hirai and Professor Takeshi Sakaba from the Graduate School of Brain Science, explores the synaptic plasticity in the links between specific regions of the hypothalamus and the hippocampus. Neuronal synapses often undergo lasting changes in their strength through neural activity, known as “synaptic plasticity.” They show that glutamate-mediated synapses from the hypothalamic supramammillary nucleus to the granule cells in the dentate gyrus undergo associative long-term potentiation. These findings can enable a more comprehensive understanding of learning and memory.
https://doi.org/10.1016/j.celrep.2022.111871.
For more details, please see the website of Organization for Research Initiatives and Development, Doshisha University.
Research News: Understanding Long-term Changes in the Synapses Between the Hypothalamus and Hippocampus
This achievement has also been featured in the “EurekAlert!.”
NEWS RELEASE 30-JAN-2023, Understanding long-term changes in the synapses between the hypothalamus and hippocampus
Reference
Himawari Hirai, Takeshi Sakaba, Yuki Hashimotodani, Subcortical glutamatergic inputs exhibit a Hebbian form of long-term potentiation in the dentate gyrus, Cell Reports, Volume 41, Issue 13, 2022, 111871, ISSN 2211-1247,https://doi.org/10.1016/j.celrep.2022.111871.
For more details, please see the website of Organization for Research Initiatives and Development, Doshisha University.
Research News: Understanding Long-term Changes in the Synapses Between the Hypothalamus and Hippocampus
This achievement has also been featured in the “EurekAlert!.”
NEWS RELEASE 30-JAN-2023, Understanding long-term changes in the synapses between the hypothalamus and hippocampus